Back

A functional variant of the SIDT2 gene involved in cholesterol transport is associated with HDL-C levels and premature coronary artery disease.

2020-09-20 genetic and genomic medicine Title + abstract only
View on medRxiv
Show abstract

Low HDL-C is the most frequent dyslipidemia in Mexicans, but few studies have examined the underlying genetic basis. Moreover, few lipid-associated variants have been tested for coronary artery disease (CAD) in Hispanic populations. Here, we performed a GWAS for HDL-C levels in 2,183 Mexican individuals, identifying 7 loci, including three with genome-wide significance and containing the candidate genes CETP, ABCA1 and SIDT2. The SIDT2 missense Val636Ile variant was associated with HDL-C levels ...

Predicted journal destinations

1
Nature Communications
483 training papers
Top 8% 11.1%
2
Human Genetics and Genomics Advances
39 training papers
#1 8.5%
3
The American Journal of Human Genetics
77 training papers
Top 2% 7.3%
4
Nature Genetics
72 training papers
Top 2% 6.0%
5
Human Molecular Genetics
28 training papers
Top 0.1% 4.7%
6
Genome Medicine
56 training papers
Top 3% 4.7%
7
Cell Genomics
34 training papers
Top 0.2% 4.7%
8
PLOS Genetics
39 training papers
Top 0.7% 3.9%
9
Scientific Reports
701 training papers
Top 69% 3.6%
10
PLOS ONE
1737 training papers
Top 88% 3.6%
11
Frontiers in Genetics
32 training papers
Top 0.5% 2.9%
12
Genetics in Medicine
57 training papers
Top 5% 2.6%
13
Circulation: Genomic and Precision Medicine
30 training papers
Top 4% 2.6%
14
eLife
262 training papers
Top 25% 1.8%
15
Journal of the American Heart Association
92 training papers
Top 9% 1.8%
16
European Journal of Human Genetics
25 training papers
Top 4% 1.3%
17
Genes
21 training papers
Top 2% 1.3%
18
BMC Medicine
155 training papers
Top 22% 1.3%
19
Proceedings of the National Academy of Sciences
100 training papers
Top 12% 1.3%
20
Nature
58 training papers
Top 5% 1.3%
21
Circulation
37 training papers
Top 6% 0.9%
22
Journal of Medical Genetics
22 training papers
Top 4% 0.9%
23
Diabetologia
23 training papers
Top 3% 0.9%
24
International Journal of Molecular Sciences
39 training papers
Top 6% 0.9%
25
Communications Biology
36 training papers
Top 4% 0.9%
26
PLOS Medicine
95 training papers
Top 19% 0.9%
27
npj Genomic Medicine
18 training papers
Top 5% 0.9%
28
Bioinformatics
24 training papers
Top 3% 0.9%
29
iScience
74 training papers
Top 15% 0.7%
30
Nature Medicine
88 training papers
Top 22% 0.7%