Mitochondria surveillance systems trigger innate immune responses to bacterial pathogens via AMPK pathway in C. elegans
Peng, D.; Sun, M.; Ju, S.; Chen, H.; Wang, S.; Lin, J.; Aroian, R.
Show abstract
Pathogen recognition and triggering pattern of host innate immune system is critical to understanding pathogen-host interaction. It is generally accepted that the microbial infection can be recognized by host via pattern-triggered immunity (PTI) or effector-triggered immunity (ETI) responses. Recently, non-PRR-mediated cellular surveillance systems have been reported as an important supplement strategy to PTI and ETI responses. However, the mechanism of how surveillance systems sense pathogens and trigger innate immune responses is largely unknown. In the present study, using Bacillus thuringiensis-Caenorhabditis elegans as a model, we found a new approach for surveillance systems to sense the pathogens through no-PPRs patterns. We reported C. elegans can monitor intracellular energy status through the mitochondrial surveillance system to triggered innate immune responses against pathogenic attack via AMP-activated protein kinase (AMPK). Consider that the mitochondria surveillance systems and AMPK are conserved components from worms to mammals, our study suggests that disrupting mitochondrial homeostasis to activate the immune system through AMPK-dependent pathways may widely existing in animals.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone 96%
- Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans 95%
- The larva and adult of Helicoverpa armigera use differential gustatory receptors to sense sugars 94%
Similar papers in this journal
- Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains 94%
- SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux 93%
- The maternal vGluT2 and embryonic mGluR3 signaling relay system controls offspring wing dimorphism in pea aphid 93%
Similar papers in this journal
- The PAF1 complex cell-autonomously promotes oogenesis in Caenorhabditis elegans 93%
- Partial exogastrulation due to apical-basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole 92%
- An ALS-associated mutant KIF5A forms oligomers and aggregates and induces neuronal toxicity 92%
Similar papers in this journal
- Differential regulation of developmental stages supports a linear model for C. elegans postembryonic development 93%
- Immune priming in the insect gut: a dynamic response revealed by ultrastructural and transcriptomic changes 93%
- Immune-mediated indirect interaction between gut microbiota and bacterial pathogens 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.