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Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome
2020-09-18
cardiovascular medicine
Title + abstract only
View on medRxiv
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AimsEarly prediction of acute coronary syndrome (ACS) is a major goal for prevention of coronary heart disease (CHD). Genetic information has been proposed to improve prediction beyond well-established clinical risk factors. While polygenic scores (PS) can capture an individuals genetic risk for ACS, its prediction performance may vary in the context of diverse correlated clinical conditions. Here, we aimed to test whether clinical conditions impact the association between PS and ACS. Methods a...
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