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No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing.
2020-09-05
psychiatry and clinical psychology
Title + abstract only
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BackgroundThe increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation of the variance in this heterogeneous condition. Peripheral blood measures of cytokines and chemokines constitute the bulk of evidence with consistent meta-analytic data implicating raised proinflammatory cytokines such as IL6, IL1{beta} and TNF. Among the potential mechanisms linking immunobiological changes to affective neurobiol...
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