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Environment and sex control lifespan and telomere length in wild-derived African killifish

Reichard, M.; Giannetti, K.; Ferreira, T.; Vrtilek, M.; Polacik, M.; Blazek, R.; Ferreira, M. G.

2020-09-03 evolutionary biology
10.1101/2020.09.03.280792 bioRxiv
Show abstract

Telomere length is correlated positively with longevity at the individual level, but negatively when compared across species. Here, we tested the association between lifespan and telomere length in African annual killifish. We analyzed telomere length in 18 Nothobranchius strains derived from diverse habitats and measured the laboratory lifespan of 14 strains of N. furzeri and N. kadleci. We found that males had shorter telomeres than females. The longest telomeres were recorded in strains derived from dry region where male lifespans were shortest. At the individual level, we detected a weak negative association between rapid juvenile growth and shorter telomeres in early adulthood. Overall, average telomere length was a good descriptor of telomere length distribution. However, within-individual telomere length spread was not related to any pattern. This substantial variation in telomere length between strains from different environments provides killifish as powerful tool to understand the evolutionarily adaptive value of telomere length.

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