Dissection of PRC1 and PRC2 recruitment in Arabidopsis connects EAR repressome to PRC2 anchoring
Calonje, M.; Baile, F.; Merini, W.; Hidalgo, I.
Show abstract
PcG complexes ensure that every cell in an organism expresses the genes needed at a particular stage, time or condition. However, it is still not fully understood how PRC1 and PRC2 are recruited to target genes in plants. Recent results in Arabidopsis support that PRC2 recruitment is mediated by different TFs. However, it is unclear how all these TFs interact with PRC2 and whether they can also recruit PRC1 activity. Here, by using a system to in vivo bind selected factors to a synthetic promoter lacking the complexity of PcG target promoters, we show that while VAL1 binding recapitulates PRC1 and PRC2 marking, the binding of other TFs only render PRC2 marking. Interestingly, all these TFs contain an EAR domain that acts as docking point for PRC2 and HDACs, connecting two different repressive mechanisms. Furthermore, we show that different TFs act synergistically in PRC2 anchoring to maintain a long-term repression.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Systematic histone H4 replacement in Arabidopsis thaliana reveals a role for H4R17 in regulating flowering time 97%
- Progressive chromatin silencing of ABA biosynthesis gene permits seed germination in Arabidopsis 97%
- Co-recognition of histone acetylation and H3K4 trimethylation by GTE4-EML complex in Arabidopsis 96%
Similar papers in this journal
- DET1-mediated COP1 regulation avoids HY5 activity over second-site targets to tune plant photomorphogenesis 97%
- The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold 97%
- The Arabidopsis histone H3K4me3-binding ALFIN-like proteins mediate histone H2A ubiquitination and coordinate diverse chromatin modifications 97%
Similar papers in this journal
Similar papers in this journal
- The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons 97%
- The Arabidopsis demethylase ROS1 cis-regulates defense genes by erasing DNA methylation at promoter-regulatory regions 96%
- Combinations of maternal-specific repressive epigenetic marks in the endosperm control seed dormancy 95%
Similar papers in this journal
- Cryptic promoter activation occurs by at least two different mechanisms in the Arabidopsis genome 96%
- Functional genetics of rice <em>PISTILLATA</em> genes unravels new roles and targets in flowering time, female fertility and parthenocarpy 95%
- SnRK1 inhibits anthocyanin biosynthesis through both transcriptional regulation and direct phosphorylation and dissociation of the MYB/bHLH/TTG1 MBW complex. 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.