Gene expression patterns in chordate embryonic development suggest partial applicability of Haeckel's postulates
Khaitovich, P.; Guo, S.; Hu, H.; Xu, C.; Irie, N.
Show abstract
The relationship between embryonic development and evolution historically investigated based on embryo morphology, could now be reassessed using mRNA expression endophenotype. Here, we investigated the applicability of von Baers and Haeckels arguments at mRNA expression level by comparing the developmental changes among nine evolutionarily distinct species: from oyster to mouse. In agreement with models based on von Baers postulates, up to 36% of mRNA expression indicated nearly linear conservation of species developmental programs. By contrast, 5-15% of developmental expression profiles, enriched in neural genes, displayed an alignment pattern compatible with the terminal edition paradigm proposed by Haeckel. Thus, the development-evolution relationship based on mRNA expression agrees with early concepts based on embryo morphology and demonstrates that the corresponding patterns coexist in chordate development.
Matching journals
The top 1 journal accounts for 50% of the predicted probability mass.
Similar papers in this journal
- Sequence heterochrony led to a gain of functionality in an immature stage of the central complex: a fly-beetle insight 93%
- Millipede genomes reveal unique adaptation of genes and microRNAs during myriapod evolution 93%
- The tricellular vertex-specific adhesion molecule Sidekick facilitates polarised cell intercalation during Drosophila axis extension 92%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.