Flagellin from Pseudomonas aeruginosa modulates SARS-CoV-2 infectivity in CF airway epithelial cells by increasing TMPRSS2 expression
Ruffin, M.; Bigot, J.; Calmel, C.; Mercier, J.; Pizzorno, A.; Rosa-Calatrava, M.; Corvol, H.; Balloy, V.; Terrier, O.; Guillot, L.
Show abstract
The major challenge of the COVID-19 health crisis is to identify the factors of susceptibility to SARS-Cov2 in order to adapt the recommendations to the populations and to reduce the risk of getting COVID-19 to the most vulnerable people especially those having chronic respiratory diseases including cystic fibrosis (CF). Airway epithelial cells (AEC) are playing a critical role in the immune response and in COVID-19 severity. SARS-CoV-2 infects the airways through ACE2 receptor and the host protease TMPRSS2 was shown to play a major role in SARS-CoV-2 infectivity. Here, we show that the main component of P. aeruginosa flagella, ie. flagellin is able to increase TMPRSS2 expression in AEC, and even more in those deficient for CFTR. Importantly, this increased TMPRSS2 expression is associated with an increase in the level of SARS-CoV-2 infection. Considering the urgency of the health situation, this result is of major significance for patients with CF which are frequently infected and colonized by P. aeruginosa during the course of the disease.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Furin Inhibition Protects Against Acute Lung Injury in a Mouse Model of Pseudomonas Aeruginosa Infection 94%
- Targeting ATP12A, a non-gastric proton pump alpha subunit, for idiopathic pulmonary fibrosis treatment 94%
- The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium 94%
Similar papers in this journal
- A porcine ex vivo lung perfusion model to investigate bacterial pathogenesis 93%
- Heterogenous susceptibility to R-pyocin killing in populations of Pseudomonas aeruginosa sourced from cystic fibrosis lungs 92%
- The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics 92%
Similar papers in this journal
- High-throughput functional analysis of CFTR and other apically localized channels in iPSC derived intestinal organoids 92%
- HSP90 modulates T2R bitter taste receptor nitric oxide production and innate immune responses in human airway epithelial cells and macrophages 92%
- DNA glycosylase NEIL2 prevents Fusobacterium-mediated inflammation and DNA damage in colonic epithelial cells 90%
Similar papers in this journal
- The SARS-CoV-2 multibasic cleavage site facilitates early serine protease-mediated entry into organoid-derived human airway cells 92%
- Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli 91%
- Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system 91%
Similar papers in this journal
- Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID 91%
- Inverse regulation of secretion and inflammation in human airway gland serous cells by neuropeptides upregulated in allergy and asthma 91%
- Single cell RNA Sequencing Identifies G-protein Coupled Receptor 87 as a Novel Basal Cell Marker of Distal Honeycomb Cysts in Idiopathic Pulmonary Fibrosis 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.