On the diversity of F420-dependent oxidoreductases: a sequence- and structure-based classification
Mascotti, M. L.; Juri Ayub, M.; Fraaije, M.
Show abstract
The F420 deazaflavin cofactor is an intriguing molecule as it structurally resembles the canonical flavin cofactor, although biochemically behaves as a nicotinamide cofactor. Since its discovery, numerous enzymes relying on it have been described. The known deazaflavoproteins are taxonomically restricted to Archaea and Bacteria. The biochemistry of the deazaflavoenzymes is diverse and they exhibit some degree of structural variability as well. In this study a thorough sequence and structural homology evolutionary analysis was performed in order to generate an overarching classification of all known F420-dependent oxidoreductases. Five different superfamilies are described: Superfamily I, TIM-barrel F420-dependent enzymes; Superfamily II, Rossmann fold F420-dependent enzymes; Superfamily III, {beta}-roll F420-dependent enzymes; Superfamily IV, SH3 barrel F420-dependent enzymes and Superfamily V, 3 layer {beta}{beta} sandwich F420-dependent enzymes. This classification aims to be the framework for the identification, the description and the understanding the biochemistry of novel deazaflavoenzymes.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Characterization of BLUF-photoreceptors present in Acinetobacter nosocomialis. 95%
- Crystal structure of β-L-arabinobiosidase belonging to glycoside hydrolase family 121 94%
- Characterization of the Corynebacterium glutamicum dehydroshikimate dehydratase QsuB and its potential for microbial production of protocatechuic acid 94%
Similar papers in this journal
- Flexibility of Short-chain dehydrogenase is interconnected to its promiscuity for the reduction of multiple ketone intermediates 94%
- Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter 92%
- Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases 92%
Similar papers in this journal
- The ADP-glucose pyrophosphorylase from Melainabacteria: a comparative study between photosynthetic and non-photosynthetic bacterial sources 95%
- Glucosamine-6P and glucosamine-1P, respectively an activator and a substrate of rhodococcal ADP-glucose pyrophosphorylases, show a hint to ascertain (actino)bacterial glucosamine metabolism 94%
- The β-lactam Ticarcillin is a Staphylococcus aureus UDP-N-acetylglucosamine 2-epimerase binder. 92%
Similar papers in this journal
- Hydroxylation of antitubercular drug candidate, SQ109, by mycobacterial cytochrome P450 92%
- Phylogenomics provides new insights into gains and losses of selenoproteins among Archaeplastida 92%
- Evolution end classification of tfd gene clusters mediating bacterial degradation of 2,4-dichlorophenoxyacetic acid (2,4-D) 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.