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Precision Colorectal Cancer Screening with Polygenic Risk Score
2020-08-22
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
Colorectal cancer (CRC) is the second most common cancer in women and third most common cancer in men. Genome-wide association studies have identified numerous genetic variants (SNPs) independently associated with CRC. The effects of such SNPs can be combined into a single polygenic risk score (PRS). Stratification of individuals according to PRS could be introduced to primary and secondary prevention. Our aim was to combine risk stratification of a sex-specific PRS model with recommendations fo...
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International Journal of Cancer
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Human Genetics and Genomics Advances
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American Journal of Gastroenterology
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