Hexosamine biosynthetic pathway integrates circadian and metabolic signals to regulate daily rhythms in protein O-linked N-acetylglucosaminylation
Liu, X.; Blazenovic, I.; Contreras, A.; Pham, T. M.; Tabuloc, C. A.; Li, Y. H.; Ji, J.; Fiehn, O.; Chiu, J. C. C.
Show abstract
The integration of circadian and metabolic signals is essential for maintaining robust circadian rhythms and ensuring efficient metabolism and energy use. Using Drosophila as an animal model, we showed that cellular protein O-linked N-acetylglucosaminylation (O-GlcNAcylation) exhibits robust 24-hour rhythm and is a key post-translational mechanism that regulates circadian physiology. We observed strong correlation between protein O-GlcNAcylation rhythms and clock-controlled feeding-fasting cycles, suggesting that O-GlcNAcylation rhythms are primarily driven by nutrient input. Interestingly, daily O-GlcNAcylation rhythms were severely dampened when we subjected flies to time-restricted feeding (TRF) at unnatural feeding time. This suggests the presence of a clock-regulated buffering mechanism that prevents excessive O-GlcNAcylation at non-optimal times of the day-night cycle. We found that this buffering mechanism is mediated by glutamine-fructose-6-phosphate amidotransferase (GFAT) activity, which is regulated through integration of circadian and metabolic signals. Finally, we generated a mathematical model to describe the key factors that regulate daily O-GlcNAcylation rhythm.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming 96%
- The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila CNS. 96%
- The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut 96%
Similar papers in this journal
Similar papers in this journal
- Precise temporal regulation of post-transcriptional repressors is required for an orderly Drosophila maternal-to-zygotic transition 94%
- Replication competition drives the selective mtDNA inheritance in Drosophila ovary 94%
- Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest 94%
Similar papers in this journal
- A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms 95%
- Antagonistic Regulation of Circadian Output and Synaptic Development by the E3 Ubiquitin Ligase JETLAG and the DYSCHRONIC-SLOWPOKE Complex 94%
- A robust and self-sustained peripheral circadian oscillator reveals differences in temperature compensation properties with central brain clocks 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.