Invasion performance-similarity found among multiple cell systems
Prakash, O.
Show abstract
Understanding of inter-system behavior develops biologically relevant intuition for drug repositioning as well as other biological research. But combining all the possible genes interactions into a system, and furthermore comparisons of multiple systems are a challenge on time ground with feasible experiments. In present study, 64 cell lines from 11 different organs were compared for their invasion performance. RNA expressions of 23 genes were used to create systems artificial neural network (ANN) models. ANN models were prepared for all 64 cell lines and observed for their invasion performance through network mapping. The resulted cell line clusters bear feasible capacity to perform experiments for biologically relevant research motivations as drug repositioning and selective targeting etc.; and can be used for analysis of invasion related aspects.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Targeting Oncogenic Mutations in Colorectal Cancer using Cryptotanshinone 95%
- Classification of early and late stage Liver Hepatocellular Carcinoma patients from their genomics and epigenomics profiles. 95%
- Directed Bayesian Networks established functional differences between breast cancer subtypes 95%
Similar papers in this journal
- Classification models for Invasive Ductal Carcinoma Progression, based on gene expression data-trained supervised machine learning 97%
- Discovering Key Transcriptomic Regulators in Pancreatic Ductal Adenocarcinoma using Dirichlet Process Gaussian Mixture Model 96%
- Comparing protein-protein interaction networks of SARS-CoV-2 and (H1N1) influenza using topological features 96%
Similar papers in this journal
- BESFA: Bioinformatics based Evolutionary, Structural & Functional Analysis of Prostrate, Placenta, Ovary, Testis, and Embryo (POTE) Paralogs 94%
- A small H2O-soluble ingredient of royal jelly lower cholesterol levels in liver cells by suppressing squalene epoxidase 94%
- A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions 94%
Similar papers in this journal
- Systems biomedicine of primary and metastatic colorectal cancer reveals potential therapeutic targets 96%
- Patient stratification of clear cell renal cell carcinoma using the global transcription factor activity landscape derived from RNA-seq data 95%
- miR-100-5p downregulates mTOR to suppress the proliferation, migration and invasion of prostate cancer cells 92%
Similar papers in this journal
- SiCoDEA: a simple, fast and complete app for analyzing the effect of individual drugs and their combinations 93%
- Can we assume the gene expression profile as a proxy for signaling network activity? 92%
- Evaluating the potential of marine invertebrate and insect protein hydrolysates to reduce fetal bovine serum in cell culture media for cultivated fish production 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.