Synaptic anchoring of the endoplasmic reticulum depends on myosin V and caldendrin activity
Konietzny, A.; Grendel, J.; Hertrich, N.; Dekkers, D. H. W.; Demmers, J. A.; Mikhaylova, M.
Show abstract
Excitatory synapses of principal hippocampal neurons are frequently located on dendritic spines. The dynamic strengthening or weakening of individual inputs results in a great structural and molecular diversity of dendritic spines. Active spines with large Ca2+ transients are frequently invaded by a single protrusion from the endoplasmic reticulum (ER), which is dynamically transported into and out of spines by the actin-based motor myosin V. An increase in synaptic strength often correlates with stable anchoring of the ER, followed by the formation of the spine apparatus organelle. Here we show that synaptic ER stabilization depends on the interplay of two Ca2+-binding proteins: calmodulin serves as a light chain of myosin V and activates the motor function, whereas caldendrin acts as an inhibitor which transforms myosin into a stationary F-actin tether. Together, they provide a Ca2+-sensing module for fine-tuning myosin V activity and thereby regulate the formation of the spine apparatus in a subset of active dendritic spines.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Carbonic anhydrase VII regulates dendritic spine morphology and density via actin filament bundling 97%
- Post-mitotic expansion of cell nuclei requires ACTN4-mediated nuclear actin filament bundling 95%
- Aurora Kinase A proximity interactome reveals centriolar satellites as regulators of its function during primary cilium biogenesis 95%
Similar papers in this journal
Similar papers in this journal
- Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis 96%
- A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation 96%
- Crosstalk between Rac and Rho GTPase activity mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cycles. 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.