Diploid hepatocytes drive physiological liver renewal in adult humans
Heinke, P.; Rost, F.; Rode, J.; Welsch, T.; Alkass, K.; Feddema, J.; Salehpour, M.; Possnert, G.; Druid, H.; Brusch, L.; Bergmann, O.
Show abstract
Physiological liver cell replacement is central to maintaining the organs high metabolic activity, although its characteristics are difficult to study in humans. Using retrospective 14C birth dating of cells, we report that human hepatocytes show continuous and lifelong turnover, maintaining the liver a young organ (average age < 3 years). Hepatocyte renewal is highly dependent on the ploidy level. Diploid hepatocytes show an seven-fold higher annual exchange rate than polyploid hepatocytes. These observations support the view that physiological liver cell renewal in humans is mainly dependent on diploid hepatocytes, whereas polyploid cells are compromised in their ability to divide. Moreover, cellular transitions between these two subpopulations are limited, with minimal contribution to the respective other ploidy class under homeostatic conditions. With these findings, we present a new integrated model of homeostatic liver cell generation in humans that provides fundamental insights into liver cell turnover dynamics.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging 94%
- A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence 93%
- Lack of evidence for increased transcriptional noise in aged tissues 93%
Similar papers in this journal
- IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration 93%
- Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging 92%
- VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis 91%
Similar papers in this journal
- Single-cell RNA sequencing identifies accumulation of Fcgr2b+ virtual memory like CD8 T cells with cytotoxic and inflammatory potential in aged mouse white adipose tissue 93%
- Cell-Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis 92%
- Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.