Loss expansion of SARS-CoV-2 specific immunity is a key risk factor in fatal patients with COVID-19
Zeng, Q.; Huang, G.; Li, Y.-z.; Xu, G.; Dong, S.-y.; Zhong, T.-y.; Chen, Z.-t.; Xu, Y.
Show abstract
Knowledge of the dynamic immunological characteristics of patients with coronavirus disease 2019 (COVID-19) is essential for clinicians to understand the progression of the disease. Our data showed that the immune system and function gradually remodeled and declined with age, starting from age 16 until age 91 in 25,239 healthy controls. An analysis of the relationship between the number of lymphocytes and age revealed that the lymphocyte and subset counts tended to decline with age significantly. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunity declined with age and was associated with survival time in fatal cases. Loss in the expansion of SARS-CoV-2-specific immunity could be expanded in vitro. The concurrent decline in SARS-CoV-2-specific cellular and humoral immunities and prolonged SARS-CoV-2 exposure predicted fatal outcomes. Our findings provide a basis for further analysis of SARS-CoV-2-specific immunity and understanding of the pathogenesis of fatal COVID-19 cases. O_LSTHighlightsC_LSTO_LIThe immune system and function gradually remodeled and declined with age. C_LIO_LISARS-CoV-2-specific immunity declined with age in fatal cases. C_LIO_LISARS-CoV-2-specific immunity was associated with survival time in fatal cases. C_LIO_LILoss in the expansion of SARS-CoV-2-specific immunity could be expanded in vitro. C_LIO_LIA concurrent decline in SARS-CoV-2-specific cellular and humoral immunities and prolonged SARS-CoV-2 exposure predicted fatal outcomes. C_LI
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Long-term T cell perturbations and waning antibody levels in individuals needing hospitalization for COVID-19 93%
- T cell activation, highly armed cytotoxic cells and a sharp shift in monocytes CD300 receptors expression is characteristic of patients with severe COVID-19 93%
- Microarray Gene Expression DatasetRe-Analysis Reveals Variability in InfluenzaInfection and Vaccination. 93%
Similar papers in this journal
Similar papers in this journal
- Genome-Wide Asymptomatic B-Cell, CD4+ and CD8+ T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus Vaccines 93%
- SARS-CoV-2 infection drives a glycan switch of peripheral T cells at diagnosis 91%
- Dickkopf1 is a Novel Endogenous Ligand for priming NLRP3 Inflammasome in Macrophages via TLR4 90%
Similar papers in this journal
- SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response 92%
- Secreted ORF8 is a pathogenic cause of severe Covid-19 and potentially targetable with select NLRP3 inhibitors 91%
- Integrated role of microRNA-30e-5p through targeting negative regulators of innate immune pathways during HBV infection and SLE 91%
Similar papers in this journal
- Persistent SARS-CoV-2 presence is companied with defects in adaptive immune system in non-severe COVID-19 patients 92%
- SARS-CoV-2-induced humoral immunity through B cell epitope analysis and neutralizing activity in COVID-19 infected individuals in Japan 92%
- Immune transcriptomes from hospitalized patients infected with the SARS-CoV-2 variants B.1.1.7 and B.1.1.7 carrying the E484K escape mutation 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.