The Drosophila MOZ homolog Enok controls Notch-dependent induction of the RUNX gene lozenge independently of its histone-acetyl transferase activity.
Genais, T.; Gigan, D.; Auge, B.; Moussalem, D.; Waltzer, L.; Haenlin, M.; Gobert, V.
Show abstract
The human KAT6 lysine acetyltransferase MOZ has been shown to be an essential player in the field of normal and malignant hematopoiesis. It belongs to a highly conserved family of epigenetic factors and remodels chromatin by acetylating histone tails in association with its partners of the ING5 complex. Here, we report that its Drosophila counterpart Enok is required during larval hematopoiesis to control the Notch-dependent induction of circulating crystal cells. In particular enok is essential to allow expression of the RUNX factor Lozenge (Lz) that controls the crystal cell specific transcriptional program. We demonstrate that this function involves neither the Eaf6 and Ing5 subunits of the Drosophila ING5 complex, nor Enok own acetyltransferase activity. We identify in lz third intron a hematopoietic enhancer, which is both required to promote expression in Notch-activated crystal cell precursors in an enok-dependent manner and bound by Enok. The non-catalytic mode of action of Enok is likely conserved in MOZ/KAT6 proteins and might be of high relevance in mammalian hematopoiesis, whether normal or malignant.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Intermediate Progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants 97%
- Niche cells regulate primordial germ cell quiescence in response to basement membrane signaling 96%
- Restricted effects of the sole C. elegans Daughterless/E homolog, HLH-2, on nervous system development 96%
Similar papers in this journal
- The vascular niche controls Drosophila hematopoiesis via Fibroblast Growth Factor signaling 97%
- Relish plays a dynamic role in the niche to modulate Drosophila bloodprogenitor homeostasis in development and infection. 96%
- The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth 96%
Similar papers in this journal
- α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domain 96%
- Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis 96%
- Ets Transcription Factor Pointed Controls Germline Survival In Drosophila 96%
Similar papers in this journal
- Imaginal disc growth factors are Drosophila Chitinase-like Proteins with roles in morphogenesis and CO2 response 95%
- Selective disruption of synaptic BMP signaling by a Smad mutation adjacent to the highly conserved H2 helix 95%
- Catalytic activity of the Bin3/MEPCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster 95%
Similar papers in this journal
- Context-specific functions of Notch in Drosophila blood cell progenitors 97%
- Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling 96%
- The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.