Concerns with the use of imputation to assign HLA allele-level typing in research predicting transplant outcomes

2020-07-21 transplantation Title + abstract only

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Incomplete information on HLA allele typing is a persistent problem when analyzing the role of Human Leukocyte Antigen (HLA) in transplantation. To refine the predictions possible with partial knowledge of HLA typing, some researchers use HaploStats statistics on the frequencies of haplotypes within specified ethnic/national populations to impute complete HLA allele typing. We evaluated methods that use imputation to predict patient outcomes after organ transplantation, with focus on prediction ...

Concerns with the use of imputation to assign HLA allele-level typing in research predicting transplant outcomes

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