Mitochondrial STAT3 regulates proliferation of tissue stem cells.
Peron, M.; Meneghetti, G.; Dinarello, A.; Betto, R. M.; Facchinello, N.; Tiso, N.; Martello, G.; Argenton, F.
Show abstract
The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem cell pluripotency and promotes their proliferation. In this work, using zebrafish, we determined in vivo that mitochondrial STAT3 regulates mtDNA transcription in embryonic and larval stem cell niches and that this activity affects their proliferation rates. As a result, we demonstrated that STAT3 import inside mitochondria requires Y705 phosphorylation by Jak2, while its mitochondrial transcriptional activity, as well as its effect on proliferation, depends on the MAPK target S727. These data were confirmed using mouse embryonic stem cells: Y705 mutated STAT3 cannot enter the mitochondrion while the S727 mutation does not affect mitochondrial import of the protein. Surprisingly, STAT3-dependent increase of mitochondrial transcription seems independent from STAT3 binding to STAT3 responsive elements. Finally, loss of function experiments, with chemical inhibition of JAK/STAT3 pathway or genetic ablation of stat3 gene, demonstrated that STAT3 is also required for cell proliferation in the intestine of zebrafish.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Hindbrain rhombomere centers harbor a heterogenous population of dividing progenitors which rely on Notch-signaling 94%
- A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development 94%
- Wwc2 is a novel cell division regulator during preimplantation mouse embryo lineage formation and oogenesis 94%
Similar papers in this journal
- Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells 95%
- Marcks and Marcks-like 1 proteins promote spinal cord development and regeneration in Xenopus 95%
- Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.