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A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

2020-07-18 hiv aids Title + abstract only
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Defining causal variation by fine-mapping can be more effective in multi-ethnic genetic studies, particularly in regions such as the MHC with highly population-specific structure. To enable such studies, we constructed a large (N=21,546) high resolution HLA reference panel spanning five global populations based on whole-genome sequencing data. Expectedly, we observed unique long-range HLA haplotypes within each population group. Despite this, we demonstrated consistently accurate imputation at G...

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