Multi-batch cytometry data integration for optimal immunophenotyping
Ogishi, M.; Yang, R.; Gruber, C.; Pelham, S.; Spaan, A. N.; Rosain, J.; Chbihi, M.; Han, J. E.; Rao, V. K.; Kainulainen, L.; Bustamante, J.; Boisson, B.; Bogunovic, D.; Boisson-Dupuis, S.; Casanova, J.-L.
Show abstract
We describe the integration of multi-batch cytometry datasets (iMUBAC), a flexible, robust, and scalable computational framework for unsupervised cell-type identification across multiple batches of high-dimensional cytometry datasets. After overlaying cells from healthy controls across multiple batches, iMUBAC learns batch-specific cell-type classification boundaries and identifies aberrant immunophenotypes in patient samples. We illustrate unbiased and streamlined immunophenotyping, using both in-house and public mass and flow cytometry datasets.
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