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Improving recombinant protein production using TISIGNER.com

Bikash K. Bhandari; Chun Shen Lim; Paul P. Gardner

2020-07-09 bioinformatics
10.1101/2020.07.09.196469 bioRxiv
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ABSTRACTPlanning experiments using accurate prediction algorithms could mitigate failures in recombinant protein production. We have developed TISIGNER.com with the aim of addressing the technical challenges in recombinant protein production. We offer two web services, TIsigner (Translation Initiation coding region designer) and SoDoPE (Soluble Domain for Protein Expression), which are specialised in prediction/optimisation of recombinant protein expression and solubility, respectively. Importantly, TIsigner and SoDoPE are linked, which allows users to switch between the tools when optimising their genes of interest.Competing Interest StatementThe authors have declared no competing interest.View Full Text

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