Confirmed central olfactory system lesions on brain MRI in COVID-19 patients with anosmia: a case-series
Girardeau, Y.; GALLOIS, Y.; DE BONNECAZE, G.; ESCUDE, B.; LAFONT, C.; CHATELLIER, G.; MARX, M.
Show abstract
ObjectiveAnosmia has been listed as a key-symptom associated with the COVID-19 infection. Because it often occurs without any sign of rhinitis, lesions of the central olfactory system have been suspected. To date, however, there is no evidence that anosmia caused by SARS-CoV2 could be the result of brain damage. MethodsWe conducted a case-series on 10 consecutive COVID-19 patients who reported anosmia. Each patient prospectively underwent a validated olfactory test (Sniffin Sticks test) and a brain MRI. Results Hypersignal intensity lesions of the central olfactory system were found in 3 subjects on 3D T2 FLAIR and 2D T2 High Resolution images with a lesion involving the olfactory bulbs and/or the orbitofrontal cortex. These 3 subjects showed a severe and persistent loss of smell on the olfactory test. Mucosal hyperplasia of the upper nasal cavities was found in two other subjects with significant smell disorders. There was no MRI anomaly in two subjects with good smell restoration. ConclusionsAnomalies of the central olfactory system could be responsible for anosmia in patients with COVID-19 infection. Further studies are needed to assess the impact on long-term functional prognosis of these lesions. Key ResultCentral anomalies of the olfactory bulb and cortex could be responsible for anosmia in COVID-19 infection
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Analysis of Extraocular muscle volumes in idiopathic Hypertrophic Pachymeningitis patients 92%
- Olfactory Dysfunction in Patients with Multiple Sclerosis; A Systematic Review and Meta-Analysis 92%
- Ocular vestibular evoked myogenic potential (VEMP) reveals subcortical HTLV-1-associated neurological disease 91%
Similar papers in this journal
- Reduced Olfactory Bulb Volume Accompanies Smelling Dysfunction After Mild SARS-CoV-2 Infection: The Hamburg City Health Study COVID Program 93%
- Radiological signs supporting idiopathic intracranial hypertension in symptomatic patients with lumbar puncture opening pressure < 250 mm. 90%
- More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis 90%
Similar papers in this journal
- Optical coherence tomography assessment of axonal and neuronal damage of the retina in patients with familial and sporadic multiple sclerosis 89%
- Factors Impacting Quality of Life in Multiple System Atrophy 89%
- Eye movement evaluation in Multiple Sclerosis and Parkinson's Disease using a Standardized Oculomotor and Neuro-ophthalmic Disorder Assessment (SONDA) 89%
Similar papers in this journal
- Cerebrospinal fluid in COVID-19 neurological complications: no cytokine storm or neuroinflammation 87%
- A Prospective Study of Long-Term Outcomes Among Hospitalized COVID-19 Patients with and without Neurological Complications 86%
- An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromso Study 86%
Similar papers in this journal
- High prevalence of long-term psychophysical olfactory dysfunction in patients with COVID-19 95%
- Objective sensory testing methods reveal a higher prevalence of olfactory loss in COVID-19 positive patients compared to subjective methods: A systematic review and meta-analysis 92%
- Persisting Chemosensory Impairments in 366 Healthcare Workers Following COVID-19: An 11-Month Follow-up 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.