Heterogeneity in the response of different subtypes of Drosophila melanogaster enteroendocrine cells to viral infections
Silva, J. M. F.; Nagata, T.; Melo, F. L.; Elena, S. F.
Show abstract
Single cell RNA sequencing (scRNA-seq) offers the possibility to monitor both host and pathogens transcriptomes at the cellular level. Here, public scRNA-seq data from Drosophila melanogaster have been used to compare the differences in replication strategy and cellular response between two viruses, Thika virus (TV) and D. melanogaster Nora virus (DMelNV) in enteroendocrine cells (EEs). TV and DMelNV exhibited different patterns of replication and for TV, accumulation varied according to cell subtype. Cells infected with TV underwent down-regulation of genes that represent bottlenecks in the fruit fly interactome, while cells infected with DMelNV went through a down-expression of translation-related genes that represent both hubs and bottlenecks in the host interactome. In contrast, flies infected with DMelNV show only a systemic level down-regulation of bottleneck genes. Here, we use scRNA-seq to highlight the differences and commonalities between cellular response to TV and DMelNV and between cellular and systemic response to DMelNV.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Comparative Genomics and Environmental Distribution of Large dsDNA viruses in the family Asfarviridae 95%
- Discovery of viral myosin genes with complex evolutionary history within plankton 95%
- In-depth Bioinformatic Analyses of Human SARS-CoV-2, SARS-CoV, MERS-CoV, and Other Nidovirales Suggest Important Roles of Noncanonical Nucleic Acid Structures in Their Lifecycles 95%
Similar papers in this journal
- Downregulation of Neurodevelopmental Gene Expression in iPSC-Derived Cerebral Organoids Upon Infection by Human Cytomegalovirus 92%
- Identification and catalogue of viral transcriptional regulators in human diseases 92%
- West Nile virus is transmitted within mosquito populations through infectious mosquito excreta 92%
Similar papers in this journal
- A tale of caution: How endogenous viral elements affect virus discovery in transcriptomic data 96%
- Genomic analysis of Ostreococcus tauri-infecting viruses reveals a hypervariable region associated with host--virus interactions 95%
- A case for a reverse-frame coding sequence in a group of positive-sense RNA viruses 95%
Similar papers in this journal
- In and outs of Chuviridae endogenous viral elements: origin of a retrovirus and signature of ancient and ongoing arms race in mosquito genomes 95%
- Identification of a new Infectious Pancreatic Necrosis Virus (IPNV) isolate in Atlantic salmon (Salmo salar L.) that causes mortality in resistant fish 93%
- Transcriptomic and epigenomic dynamics of honey bees in response to lethal IAPV viral infection 93%
Similar papers in this journal
- Molecular features similarities between SARS-CoV-2, SARS, MERS and key human genes could favour the viral infections and trigger collateral effects 93%
- Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection 93%
- Evolutionary dynamics of Tomato spotted wilt virus within and between alternate plant hosts and thrips 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.