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An in-vitro BBB-on-a-chip open model of human blood-brain barrier enabling advanced optical imaging

Salman, M.; Marsh, G.; Kusters, I.; Delince, M.; Di Caprio, G.; Upadhyayula, S.; De Nola, G.; Hunt, R.; Ohashi, K. G.; Shimizu, F.; Sano, Y.; Kanda, T.; Obermeier, B.; Kirchhausen, T.

2020-07-01 bioengineering
10.1101/2020.06.30.175380 bioRxiv
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ABSTRACTWe describe here the design and implementation of an in-vitro BBB-on-a-chip open model system capable of reconstituting the microenvironment of the blood brain barrier. This system allows controlled unidirectional flow of nutrients and biologicals on the lumen of the artificial microvessel. This BBB-on-a-chip is suitable for high resolution electron microscopy and it is amenable for quantitative 3D live fluorescence imaging using spinning confocal disk or lattice light sheet microscopy (LLSM) to follow, for example the transcytosis across the BBB-like barrier of fluorescently-tagged biological, viruses or nanoparticles.Competing Interest StatementG.M. and B.O. are employees and shareholders of Biogen. T.K. is a visiting scientist at Biogen.View Full Text

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