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Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxis

Mok, C. K.; Ng, Y. L.; Ahidjo, B. A.; Lee, R. C. H.; Loe, M. W. C.; Liu, J.; Tan, K. S.; Kaur, P.; Chng, W. J.; Wong, J. E. L.; Wang, D. Y.; Hao, E. W.; Hao, X.; Tan, Y. W.; Mak, T. M.; Lin, C.; Lin, R. V. T. P.; Tambyah, P. A.; Deng, J.; Chu, J. J. H.

2020-06-22 microbiology
10.1101/2020.06.21.162396 bioRxiv
Show abstract

COVID-19, the disease caused by SARS-CoV-2 (1), was declared a pandemic by the World Health Organization (WHO) in March 2020 (2). While awaiting a vaccine, several antivirals are being used to manage the disease with limited success (3, 4). To expand this arsenal, we screened 4 compound libraries: a United States Food and Drug Administration (FDA) approved drug library, an angiotensin converting enzyme-2 (ACE2) targeted compound library, a flavonoid compound library as well as a natural product library. Of the 121 compounds identified with activity against SARS-CoV-2, 7 were shortlisted for validation. We show for the first time that the active form of Vitamin D, calcitriol, exhibits significant potent activity against SARS-CoV-2. This finding paves the way for consideration of host-directed therapies for ring prophylaxis of contacts of SARS-CoV-2 patients.

Matching journals

The top 7 journals account for 50% of the predicted probability mass.

1
Antiviral Research
○ 50 papers in training set
Top 0.1%
15.4%
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2
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Top 18%
9.9%
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3
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Top 0.3%
9.1%
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4
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Top 0.5%
4.4%
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● 40 papers in training set
Top 0.2%
3.3%
7
ACS Infectious Diseases
● 82 papers in training set
Top 0.4%
3.2%
50% of probability mass above
8
Journal of Medical Virology
○ 140 papers in training set
Top 0.9%
2.7%
9
Viruses
○ 332 papers in training set
Top 2%
2.4%
10
International Journal of Molecular Sciences
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Top 7%
2.0%
11
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○ 37 papers in training set
Top 0.3%
1.8%
12
Proceedings of the National Academy of Sciences
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Top 27%
1.7%
13
Microbiology Spectrum
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Top 7%
1.7%
14
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○ 34 papers in training set
Top 0.5%
1.5%
15
Journal of Virology
● 499 papers in training set
Top 2%
1.5%
16
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● 833 papers in training set
Top 9%
1.4%
17
eLife
● 5828 papers in training set
Top 55%
1.4%
18
PLOS Pathogens
● 820 papers in training set
Top 7%
1.2%
19
ACS Omega
● 105 papers in training set
Top 2%
1.2%
20
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○ 106 papers in training set
Top 2%
1.2%
21
The Journal of Infectious Diseases
◐ 202 papers in training set
Top 3%
1.2%
22
eBioMedicine
○ 183 papers in training set
Top 4%
1.2%
23
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○ 39 papers in training set
Top 1%
1.1%
24
Nature Communications
○ 5641 papers in training set
Top 55%
0.9%
25
ERJ Open Research
● 47 papers in training set
Top 0.7%
0.9%
26
Virology
○ 61 papers in training set
Top 1%
0.9%
27
Frontiers in Immunology
○ 638 papers in training set
Top 9%
0.9%
28
SLAS Discovery
○ 25 papers in training set
Top 0.3%
0.9%
29
iScience
○ 1154 papers in training set
Top 39%
0.6%
30
Biochemical and Biophysical Research Communications
○ 84 papers in training set
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.