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Are men who smoke at higher risk for a more severe case of COVID-19 than women who smoke? A Systematic Review

Rodgers, A.; Indreberg, E. K.; Alfallaj, L.; Nadkarni, M.; Kabir, Z.

2020-06-22 public and global health
10.1101/2020.06.18.20135111 medRxiv
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BackgroundThe novelty of the Covid-19 pandemic is reflected in the lack of literature available for the impact of smoking on the intensity of the COVID-19 clinical manifestations. Our study tries to address this gap. MethodSix cohorts from China were analysed and a crude odds ratio was manually calculated. ResultsPatients with a smoking history were approximately 2 times (95% CI= 1.036-1.883) as likely to suffer from severe clinical manifestations of COVID-19 compared to patients without a smoking history. A higher percentage of males suffer more severe symptoms of COVID-19 in comparison to females, but this could be associated with the gender specific smoking trends observed in China. ConclusionThe gender specific smoking trends could be associated with the increased severity of COVID-19 disease manifestations in the male population.

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