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Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19

Oja, A. E.; Saris, A.; Ghandour, C. A.; Kragten, N. A. M.; Hogema, B. M.; Nossent, E. J.; Heunks, L. M. A.; Cuvalay, S.; Slot, E.; Swaneveld, F. H.; Vrielink, H.; Rispens, T.; van der Schoot, E.; van Lier, R. A. W.; Ten Brinke, A.; Hombrink, P.

2020-06-18 immunology
10.1101/2020.06.18.159202 bioRxiv
Show abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. Understanding both the immunological processes providing specific immunity and potential immunopathology underlying the pathogenesis of this disease may provide valuable insights for potential therapeutic interventions. Here, we quantified SARS-CoV-2 specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4+ T cell responses were qualitatively impaired in critically ill patients. Strikingly, however, in these patients the specific IgG antibody response was remarkably strong. The observed disparate T and B cell responses could be indicative of a deregulated immune response in critically ill COVID-19 patients.

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