Early diversity in the firing pattern of embryonic Renshaw cells: just a synergy between two opposite voltage-dependent currents
Boeri, J.; Meunier, C.; Le Corronc, H.; Branchereau, P.; Timofeeva, Y.; Lejeune, F.-X.; Mouffle, C.; Arulkandarajah, H.; Mangin, J. M.; Legendre, P.; Czarnecki, A.
Show abstract
Renshaw cells (V1R) are excitable as soon as they reach their final location next to the spinal motoneurons and are functionally heterogeneous. Using multiple experimental approaches, in combination with biophysical modeling and dynamical systems theory, we analyzed, for the first time, the mechanisms underlying the electrophysiological properties of V1R during early embryonic development of the spinal cord locomotor networks (E11.5-E16.5). We found that these interneurons are subdivided into several functional clusters from E11.5 and then display an unexpected transitory involution process during which they lose their ability to sustain tonic firing. We demonstrated that the essential factor controlling the diversity of the discharge pattern of embryonic V1R is the ratio of a persistent sodium conductance to a delayed rectifier potassium conductance. Taken together, our results reveal how a simple mechanism, based on the synergy of two voltage-dependent conductances that are ubiquitous in neurons, can produce functional diversity in V1R and control their early developmental trajectory.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Analogue signaling of somato-dendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons 95%
- Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex 95%
- Organelle calcium-derived voltage oscillations in pacemaker neurons drive food-seeking behavior in Aplysia 94%
Similar papers in this journal
- Modelling the spatial and temporal constrains of the GABAergic influence on neuronal excitability 97%
- Interleaved single and bursting spiking resonance in neurons 96%
- Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons 95%
Similar papers in this journal
- Particle-Swarm Based Modelling Reveals Two Distinct Classes of CRHPVN Neurons 94%
- Modulation of cortical slow oscillatory rhythm by GABAB receptors: an experimental and computational study 94%
- M-type potassium currents differentially affect activation of motoneuron subtypes and tune recruitment gain 93%
Similar papers in this journal
- Dynamic gain decomposition reveals functional effects of dendrites, ion channels and input statistics in population coding 96%
- The input-output relation of primary nociceptive neurons is determined by the morphology of the peripheral nociceptive terminals 95%
- Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.