Quantum dot probes for the quantitative study of drug transport by the MacAB TolC efflux pump in lipid scaffolds
Souabni, H.; Batista dos Santos, W.; Cece, Q.; Puvanendran, D.; Picard, M.
Show abstract
ABC tripartite efflux pumps are macromolecular membrane protein machineries that expel a large variety of drugs and export virulence factors from Gram negative bacteria. Using a lipid scaffold mimicking the two-membrane environment of the transporter and designing spectroscopic conditions allowing the monitoring of both ATP hydrolysis and substrate transport in real time, we show that MacAB-TolC accommodates transport and energy consumption with high coupling efficiency.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- In vitro synthesis and reconstitution using mammalian cell-free lysates enables the systematic study of the regulation of LINC complex assembly 94%
- Redefining the structure of tip-links in hair-cells 94%
- A monochromatically excitable green-red dual-fluorophore fusion incorporating a new large Stokes shift fluorescent protein 93%
Similar papers in this journal
- Ratiometric fluorescence nanoscopy and lifetime imaging of novel Nile Red analogs for analysis of membrane packing in living cells 93%
- Targeting c-Myc with a novel Peptide Nuclear Delivery Device 93%
- Preferential phosphatidylinositol 5-phosphate binding contributes to a destabilization of the VHS domain structure of Tom1 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.