Remdesivir but not famotidine inhibits SARS-CoV-2 replication in human pluripotent stem cell-derived intestinal organoids
Krueger, J.; Gross, R.; Conzelmann, C.; Mueller, J. A.; Koepke, L.; Sparrer, K.; Schuetz, D.; Seufferlein, T.; Barth, T. F. E.; Stenger, S.; Heller, S.; Kleger, A.; Muench, J.
Show abstract
Gastrointestinal symptoms in COVID-19 are associated with prolonged symptoms and increased severity. We employed human intestinal organoids derived from pluripotent stem cells (PSC-HIOs) to analyze SARS-CoV-2 pathogenesis and to validate efficacy of specific drugs in the gut. Certain, but not all cell types in PSC-HIOs express SARS-CoV-2 entry factors ACE2 and TMPRSS2, rendering them susceptible to SARS-CoV-2 infection. Remdesivir, a promising drug to treat COVID-19, effectively suppressed SARS-CoV-2 infection of PSC-HIOs. In contrast, the histamine-2-blocker famotidine showed no effect. Thus, PSC-HIOs provide an interesting platform to study SARS-CoV-2 infection and to identify or validate drugs.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC 91%
- Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas 91%
- E prostanoid receptor 4 expressing macrophages promote the regeneration of the intestinal epithelial barrier upon inflammation 91%
Similar papers in this journal
- Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness 93%
- Intestinal Bacteria Maintain Adult Enteric Nervous System and Nitrinergic Neurons via Toll-like Receptor 2-induced Neurogenesis in Mice 92%
- Commensal-derived succinate enhances tuft cell specification and suppresses ileal inflammation 91%
Similar papers in this journal
- Proliferative cell targeting and epithelial cell turnover fuels hepatitis E virus replication in human intestinal enteroids 93%
- Eicosanoids in the pancreatic tumor microenvironment: a multicellular, multifaceted progression 90%
- Single-cell lineage trajectory defines CDK inhibitor-sensitive cells-of-origin in esophageal squamous cell cancer 90%
Similar papers in this journal
- Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia 93%
- Loss of PI3-kinase activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis 93%
- Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform 92%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.