EXOC1 regulates cell morphology of spermatogonia and spermatocytes in mice
Osawa, Y.; Usui, M.; Kuba, Y.; Le, H. T.; Mikami, N.; Nakagawa, T.; Daitoku, Y.; Katok, K.; Shawki, H. H.; Ikeda, Y.; Kuno, A.; Morimoto, K.; Tanimoto, Y.; Dinh, T. T. H.; Murata, K.; Yagami, K.-i.; Ema, M.; Yoshida, S.; Takahashi, S.; Mizuno, S.; Sugiyama, F.
Show abstract
Spermatogenesis requires high regulation of germ cell morphology. The spermatogonia regulates its differentiation state by its own migration. The male germ cells differentiate and mature with the formation of syncytia, failure of forming the appropriate syncytia results in the arrest of spermatogenesis at the spermatocyte stage. However, the detailed molecular mechanisms of male germ cell morphological regulation are unknown. Here, we found that EXOC1 is important for the pseudopod formation of spermatogonia and spermatocyte syncytia in mice. We found that while EXOC1 contributes to the inactivation of Rac1 in the pseudopod formation of spermatogonia, in spermatocyte syncytium formation, EXOC1 and SNAP23 cooperate with STX2. Our results showed that EXOC1 functions in concert with various cell morphology regulators in spermatogenesis. Since EXOC1 is known to bind to several cell morphogenesis factors, this study is expected to be the starting point for the discovery of many morphological regulators of male germ cells.
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