Coordinated periodic expression of the imprinted network genes in the hair follicle growth cycle.
Marr, A. K.; Boughorbel, S.; Chouchane, A. I.; Kino, T.
Show abstract
1.Imprinted genes help mediate embryonic cell proliferation and differentiation, but their roles after birth are far less well understood. A subset of 16 imprinted gene network (IGN) genes is expressed at higher levels in stem cell progenitor cells of adult skeletal muscle and epidermis compared to their differentiated counterparts. While these genes function in muscle regeneration, their role in the skin is poorly understood. We assessed the expression profiles of these 16 IGN genes in publicly available datasets and revealed elevated expression of IGN genes in the telogen and early anagen phases in mouse skin. We also identified IGN genes among a list of previously identified hair cycle-associated genes. Furthermore, our results suggest that IGN genes form part of a larger network and function predominantly as upstream regulators of hair cycle-regulated genes. Based on these in silico data, we propose a potential novel role of these 16 IGN genes as upstream regulators of hair cycle-associated genes. We speculate that IGN gene dysregulation participates in syndromes characterized by an impaired hair cycle. Thus, IGN gene expression might serve as a point of therapeutic intervention for patients suffering from cutaneous pathologies such as common hair-loss disorders.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Disrupted Cholesterol Biosynthesis and Hair Follicle Stem Cell Impairment in the Onset of Alopecia 94%
- Melanocytes determine angiogenesis gene expression across human tissues 93%
- Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis 92%
Similar papers in this journal
- Analysis of nucleotide variations in human g-quadruplex forming regions associated with disease states 90%
- Robust genetic analysis of the X-linked anophthalmic (Ie) mouse 90%
- Array Comparative Genomic Hybridisation and Droplet Digital PCR uncover recurrent copy number variation of the titin segmental duplication region 89%
Similar papers in this journal
Similar papers in this journal
- The usage of human IGHJ genes follows a particular nonrandom selection: The recombination signal sequence affects the usage of human IGHJ genes 91%
- Computing Skin Cutaneous Melanoma Outcome from the HLA-alleles and Clinical Characteristics 90%
- Deletion of FUNDC2 and CMC4 on chromosome Xq28 is sufficient to cause hypergonadotropic hypogonadism in men 90%
Similar papers in this journal
- NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss 92%
- Redefining the PTEN Promoter: Identification of Two Upstream Transcription Start Regions 90%
- Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.