Back

A simplified model for the analysis of COVID-19 evolution during the lockdown period in Italy

Simeone, R.

2020-06-05 infectious diseases
10.1101/2020.06.02.20119883
Show abstract

A simplified model applied to COVID-19 cases detected and officially published by the italian government [1], seems to fit quite well the time evolution of the disease in Italy during the period feb-24th - may-19th 2020. The hypothesis behind the model is based on the fact that in the lockdown period the infection cannot be transmitted due to social isolation and, more generally, due to the strong protection measures in place during the observation period. In this case a compartment model is used and the interactions between the different compartments are simplified. The sample of cases detected is intended as a set of individuals susceptible to infection which, after being exposed and undergoing the infection, were isolated ( treated) in such a way they can no longer spread the infection. The values obtained are to be considered indicative. The same model has been applied both to the data relating to Italy and to some regions of Italy (Lombardia, Piemonte, Lazio, Campania, Calabria, Sicilia, Sardegna), generally finding a good response and indicatively interesting values (see chap. 5). The only tuning parameter is the incubation period{tau} that, together with the calculated growth rate{kappa} of the exponential curve used to approximate the early stage data, in this modelization, are in strong relationship with the compartments transfer rates. In particular[R] 0 and the numerical value of{kappa} (dimensionless) in this model are linked by the relation:[R] 0 = 1/{kappa}2 Revision HistoryO_ST_ABSRevision # 1C_ST_ABSO_LIErrata corrige in section 1 (Introduction): the equations that summarize the relationship between the parameters were wrong. This revised version contains the correct equations at page 2. C_LIO_LIThe synchronization criteria is updated. No need to use a threshold different to the one used to determine the growth coefficient. The results are now updated with the synchronization point near to the 20% of the maximum value of the cases detected per day: O_FD O_INLINEFIG[Formula 1]C_INLINEFIGM_FD(1)C_FD C_LIO_LIModifications in section 4 (Model results for Italy). It is appropriate to use an exponential function instead of a logistic function to find the growth rate in the initial phase. Section 4 and the results are now updated. C_LIO_LISome non-substantial corrections in the descriptive part. C_LI Revision # 2O_LIErrata corrige in the system differential equation 6: in the the derivative of S were reported a wrong additional term N. Now the equation 6 is correct. C_LI

Matching journals

The top 9 journals account for 50% of the predicted probability mass.

1
PLOS ONE
based on 1737 papers
Top 47%
11.0%
2
Scientific Reports
based on 701 papers
Top 17%
10.0%
3
Infection, Genetics and Evolution
based on 14 papers
Top 0.1%
8.1%
4
Infectious Disease Modelling
based on 50 papers
Top 0.6%
7.4%
5
Royal Society Open Science
based on 49 papers
Top 0.9%
4.4%
6
Frontiers in Public Health
based on 135 papers
Top 10%
2.8%
7
PeerJ
based on 46 papers
Top 3%
2.4%
8
International Journal of Environmental Research and Public Health
based on 116 papers
Top 10%
2.4%
9
Journal of Clinical Medicine
based on 77 papers
Top 7%
2.4%
50% of probability mass above
10
Frontiers in Medicine
based on 99 papers
Top 8%
2.4%
11
Epidemics
based on 96 papers
Top 4%
2.3%
12
Infectious Diseases
based on 15 papers
Top 0.2%
2.3%
13
Viruses
based on 79 papers
Top 2%
2.2%
14
Heliyon
based on 57 papers
Top 3%
2.2%
15
Science of The Total Environment
based on 80 papers
Top 3%
1.7%
16
BMC Infectious Diseases
based on 110 papers
Top 13%
1.3%
17
Journal of Medical Virology
based on 95 papers
Top 7%
1.3%
18
Communications Medicine
based on 63 papers
Top 2%
1.3%
19
Epidemiology and Infection
based on 80 papers
Top 8%
1.2%
20
PLOS Neglected Tropical Diseases
based on 166 papers
Top 11%
0.8%
21
Sensors
based on 18 papers
Top 3%
0.8%
22
BMJ Open
based on 553 papers
Top 51%
0.8%
23
Computers in Biology and Medicine
based on 39 papers
Top 7%
0.8%
24
Journal of Public Health
based on 23 papers
Top 3%
0.8%
25
Frontiers in Physics
based on 11 papers
Top 2%
0.8%
26
Mathematical Biosciences
based on 15 papers
Top 3%
0.7%
27
PLOS Computational Biology
based on 141 papers
Top 11%
0.7%
28
BMC Medical Research Methodology
based on 41 papers
Top 7%
0.7%
29
Eurosurveillance
based on 77 papers
Top 10%
0.7%
30
BMC Public Health
based on 148 papers
Top 25%
0.7%