Mendelian randomization analysis to characterize causal association between coronary artery disease and COVID-19
Wu, L.; Zhu, J.; Wu, C.
Show abstract
Observational studies have suggested that having coronary artery disease increases the risk of Coronavirus disease 2019 (COVID-19) susceptibility and severity, but it remains unclear if this association is causal. Inferring causation is critical to facilitate the development of appropriate policies and/or individual decisions to reduce the incidence and burden of COVID-19. We applied Two-sample Mendelian randomization analysis and found that genetically predicted CAD was significantly associated with higher risk of COVID-19: the odds ratio was 1.29 (95% confidence interval 1.11 to 1.49; P = 0.001) per unit higher log odds of having CAD.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Association of Cardiologist Clinic Visits with Cardiovascular Primary Prevention Outcomes Among People with HIV from Underrepresented Racial and Ethnic Groups in the Southern United States 92%
- Epigenomic prediction of cardiovascular disease risk and interactions with traditional risk metrics 91%
- Leveraging genetic data to elucidate the relationship between Covid-19 and ischemic stroke 91%
Similar papers in this journal
- Validation of genome-wide polygenic risk scores for coronary artery disease in French Canadians 94%
- An integrated polygenic and clinical risk tool enhances coronary artery disease prediction 93%
- A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men 91%
Similar papers in this journal
- Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study 91%
- Reduction of clonal hematopoiesis mutation burden in coronary patients treated with low-dose colchicine 91%
- High-sensitivity cardiac troponin on presentation to rule out myocardial infarction: a stepped-wedge cluster randomised controlled trial 91%
Similar papers in this journal
- Actionable absolute risk prediction of atherosclerotic cardiovascular disease: a behavior-management approach based on data from 464,547 UK Biobank participants 91%
- Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium 91%
- GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations 90%
Similar papers in this journal
- Comparative Effectiveness of Second-line Antihyperglycemic Agents for Cardiovascular Outcomes: A Large-scale, Multinational, Federated Analysis of the LEGEND-T2DM Study 91%
- Joint Association of Polygenic Risk and Social Determinants of Health with Coronary Heart Disease in the United States 91%
- Assessment of valvular function in over 47,000 people using deep learning-based flow measurements 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.