Genetic, lifestyle and environmental risk factors for chronic pain revealed through GWAS
Lundberg, M.; Campos Gonzalez, A. I.; Farrell, S. F.; Wang, G.; Sterling, M.; Renteria, M. E.; Ngo, T. T.; Cuellar Partida, G.
Show abstract
Chronic pain (CP) is a leading cause of disability worldwide with complex aetiologies that remain elusive. Here we addressed this issue by performing a GWAS on a large UK Biobank sample (N=188,352 cases & N=69,627 controls) which identified two independent loci associated with CP near ADAMTS6 and LEMD2. Gene-based tests revealed additional CP-associated genes (DCAKD, NMT1, MLN, IP6K3). Across 1328 complex traits, 548 (41%) were genetically correlated with CP, of which 175 (13%) showed genetic causal relationships using the latent causal variable approach and Mendelian randomization. In particular, major depressive disorder, anxiety, smoking, body fat & BMI were found to increase the risk of CP, whereas diet, walking for pleasure & higher educational attainment were associated with a reduced risk (i.e., protective effect). This data-driven hypothesis-free approach has uncovered several specific risk factors that warrant further examination in longitudinal trials to help deliver effective early screening & management strategies for CP.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort 92%
- Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders 91%
- COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases 91%
Similar papers in this journal
- A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank 95%
- Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control. 92%
- Common genetic variants with fetal effects on birth weight are enriched for proximity to genes implicated in rare developmental disorders 90%
Similar papers in this journal
- Neuronal complexity is attenuated in chronic migraine and restored by HDAC6 inhibition 91%
- Co-expression analysis reveals interpretable gene modules controlled by trans-acting genetic variants 90%
- Integrated Analyses of Growth Differentiation Factor-15 Concentration and Cardiometabolic Diseases in Humans 90%
Similar papers in this journal
- Genome-wide association study of neuropathic pain phenotypes implicates loci involved in neural cell adhesion, channels, collagen matrix formation and immune regulation 93%
- Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception 92%
- The impact of chronic pain on brain gene expression 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.