Early antibody response to SARS-CoV-2
Dittadi, R.; Afshar, H.; Carraro, P.
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BackgroundThe role and significance of the immune response to SARS-CoV-2 infection is not yet well known. MethodsWe conducted a study on 46 symptomatic subjects with disease confirmed by laboratory tests, to evaluate the presence of IgG and IgM antibodies in these subjects in relation to the time elapsed since the onset of symptoms. The analytical performance of the method used in the study and the effect of two different serum and plasma matrices were also assessed. ResultsIgG positivity was demonstrated in 100% of cases 15 days after the onset of the disease. IgM show lower concentrations and do not exceed 77% of cases after 15 days. The analytical performance of the method used (Maglumi 800, Snibe, China) was confirmed to be good in terms of imprecision, linearity and commutability in two sample matrix. ConclusionThe serological study through the search for specific IgG for SARS-CoV-2 results to be sensitive and suitable for population research and evidences that this approach can also play an important role in diagnosis. The diagnostic performance of specific IgMs are lower.
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