Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
Kuri-Cervantes, L.; Pampena, M. B.; Meng, W.; Rosenfeld, A. M.; Ittner, C. A. G.; Weisman, A. R.; Agyekum, R.; Mathew, D.; Baxter, A. E.; Vella, L.; Kuthuru, O.; Apostolidis, S.; Bershaw, L.; Dougherty, J.; Greenplate, A. R.; Pattekar, A.; Kim, J.; Han, N.; Gouma, S.; Weirick, M. E.; Arevalo, C. P.; Bolton, M. J.; Goodwin, E. C.; Anderson, E. M.; Hensley, S. E.; Jones, T. K.; Mangalmurti, N. S.; Luning Prak, E. T.; Meyer, N. J.; Kim, J.; Betts, M. R.
Show abstract
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populations, profound plasmablast expansion, and SARS-CoV-2-specific antibodies in many, but not all, severe COVID-19 cases. Despite this heterogeneity, we found selective clustering of severe COVID-19 cases through unbiased analysis of the aggregated immunological phenotypes. Our findings demonstrate broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation. One Sentence SummaryBroad immune perturbations in severe COVID-19
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Human ASXL1 Deficiency Causes Epigenetic Dysfunction, Combined Immunodeficiency and EBV–Associated Hodgkin Lymphoma 94%
- Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19 94%
- A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis 94%
Similar papers in this journal
- The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity 94%
- Profile of SARS-CoV-2-specific CD4 T cell response: Relationship with disease severity and impact of HIV-1 and active Mycobacterium tuberculosis co-infection 94%
- Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis 94%
Similar papers in this journal
- Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity 94%
- Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset 94%
- Immunophenotyping and machine learning identify distinct immunotypes that predict COVID-19 clinical severity 94%
Similar papers in this journal
- Dysregulated immune responses in COVID-19 patients correlating with disease severity and invasive oxygen requirements 95%
- ScRNA-Seq study of neutrophils reveals vast heterogeneity and breadth of inflammatory responses in severe COVID-19 patients 95%
- A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients 94%
Similar papers in this journal
- Seroconversion stages COVID19 into distinct pathophysiological states 94%
- Prolonged T-cell activation and long COVID symptoms independently associate with severe disease at 3 months in a UK cohort of hospitalized COVID-19 patients 94%
- Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.