Time-dependent roles of adolescent- and adult-born dentate granule neurons in spatial learning
Masachs, N.; Charrier, V.; Farrugia, F.; Lemaire, V.; Mazier, W.; Blin, N.; Tronel, S.; Montaron, M.-F.; Ge, S.; Cota, D.; Deroche-Gamonet, V.; Herry, C.; Abrous, N.
Show abstract
The dentate gyrus presents the peculiarity to be formed after birth in rodents. Adolescence is a very sensitive period during which cognitive competences are programmed. We investigated and compared the role of dentate neurons born during adolescence or generated during adulthood. We demonstrated that the ontogenetic stage of dentate neurons in relation to when they are generated dictates their participation in memory processes.
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