Myosin 10 and a Cytoneme-Localized Ligand Complex Promote Morphogen Transport
Hall, E. T.; Stewart, D. P.; Dillard, M.; Wagner, B.; Temirov, J.; Cheney, R. E.; Mori, M.; Robinson, C. G.; Ogden, S. K.
Show abstract
Morphogens function in concentration-dependent manners to instruct cell fate during tissue patterning. Molecular mechanisms by which these signaling gradients are established and reinforced remain enigmatic. The cytoneme transport model posits that specialized filopodia extend between morphogen-sending and responding cells to ensure that appropriate signal activation thresholds are achieved across developing tissues. How morphogens are transported along and deployed from cytonemes is not known. Herein we show that the actin motor Myosin 10 promotes cytoneme-based transport of Sonic Hedgehog (SHH) morphogen to filopodial tips, and that SHH movement within cytonemes occurs by vesicular transport. We demonstrate that cytoneme-mediated deposition of SHH onto receiving cells induces a rapid signal response, and that SHH cytonemes are promoted by a complex containing a ligand-specific deployment protein and associated co-receptor. One-Sentence summaryCytoneme-based delivery of the Sonic Hedgehog activation signal is promoted by Myosin 10 and BOC/CDON co-receptor function.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stability 97%
- A Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation 96%
- Evolutionarily related small viral fusogens hijack distinct but modular actin nucleation pathways to drive cell-cell fusion 96%
Similar papers in this journal
- C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility 95%
- An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis 95%
- Membrane-associated periodic skeleton regulates major forms of endocytosis in neurons through a signaling-driven positive feedback loop 95%
Similar papers in this journal
- Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly 97%
- CYRI-A regulates macropinocytic cup maturation and mediates integrin uptake, limiting invasive migration 95%
- Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability 95%
Similar papers in this journal
- The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and Cilia to Regulate Ciliogenesis and Ciliary Protein Traffic 95%
- Non-muscle myosin-2 contractility-dependent actin turnover limits the length of epithelial microvilli 95%
- Spatial Regulation of MCAK Promotes Cell Polarization and Focal Adhesion Turnover to Drive Robust Cell Migration 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.