Pontine Lesions Impair Visually Guided Eye and Hand Movements
Bunjes, F.; Thier, H.-P.
Show abstract
Although animal research and some rare human case reports suggest that lesions of the dorsal pons yield saccadic and smooth pursuit eye movement deficits, little is known about the functional topology of the human pontine nuclei (PN) and whether limb movements are similarly affected as eye movements. Saccadic as well as SP eye and pointing movements were measured in six patients with lesions in the PN region. Five patients of the six exhibited dysmetric saccades, whilst smooth pursuit gain was reduced in four. Pontine lesions also alter the relationship between amplitude, velocity, and velocity skewness of saccadic eye movements. Limb movement trajectories were more curved in four patients. The results suggest that the lesions impair a general calibration mechanism that uses the parallel fiber-Purkinjecell synapse in the cerebellar cortex to adjust the timing of muscle innervation in visually guided oculomotor as well as limb movement tasks.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Eye movement evaluation in Multiple Sclerosis and Parkinson's Disease using a Standardized Oculomotor and Neuro-ophthalmic Disorder Assessment (SONDA) 91%
- Modulation of Corticospinal Excitability and Muscle Synergies During Complex Locomotor Task in Individuals With and Without Cerebral Palsy: A TMS and EMG Study 88%
- Abnormal synergies and associated reactions post-hemiparetic stroke reflect the neuroanatomy of brainstem motor pathways 88%
Similar papers in this journal
- Impairment but not abolishment of express saccades after unilateral- or bilateral cryogenic FEF inactivation 92%
- Laryngeal and swallow dysregulation following acute cervical spinal cord injury 91%
- Integration of vestibular and hindlimb inputs by vestibular nucleus neurons: Multisensory influences on postural control. 90%
Similar papers in this journal
- A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex 90%
- A novel extra-venous pathway drains CSF from the subarachnoid space to thoracic duct: the CSF canalicular system. Implications for space-flight associated neuro-ocular syndrome 90%
- Torsion-Induced Traumatic Optic Neuropathy (TITON): A Physiologically Relevant Animal Model of Traumatic Optic Neuropathy 89%
Similar papers in this journal
- Increased axon initial segment length results in increased Na+ currents in spinal motoneurones at symptom onset in the G127X SOD1 mouse model of Amyotrophic Lateral Sclerosis. 89%
- GABAA receptors are selectively expressed in NG2 glia of the cerebellar white matter 89%
- Structural and functional plasticity in the dorsolateral geniculate nucleus of mice following bilateral enucleation 89%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.