Frequency of Hepatitis B, C and HIV infections among transfusion-dependent Beta Thalassemia patients in Dhaka

Transfusion transmitted infections (TTIs) have remained a major deterrent to public health, particularly among the patients with transfusion-dependent Beta thalassemia in developing countries. Although proper donor selection through adoption of WHO-advised infection panel has lowered the rate of infections, the multi-transfused patients are not free of risk. The present study screened 148 transfusion-dependent Beta thalassemia patients to determine the frequency of HCV, HBV and HIV using ELISA method. Among these patients, infected cases with HCV, HBV and HIV were 13.51%, 3.37% and 0%, respectively. Moreover, 2% of the patients had co-infections with both HBV and HCV. The percentage of infections in the patients with frequent transfusion interval ([&le;]30 days) was significantly higher (P<0.0005) than that in the patients with less frequent transfusion intervals (>30 days). Immunochromatography (ICT)-based rapid test kits are usually used to screen and confirm these infections in the blood of the patients. However, ICT-based tests are not sensitive enough to detect the infections. So, a combination of both Nucleic Acid testing (NAT) and serological testing are suggested to significantly reduce the risk of viral infections during blood transfusion.