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The Approved Dose of Ivermectin Alone is not the Ideal Dose for the Treatment of COVID-19
2020-04-26
pharmacology and therapeutics
Title + abstract only
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IntroductionCaly, Druce (1) reported that ivermectin inhibited SARS-CoV-2 in vitro for up to 48 h using ivermectin at 5M. The concentration resulting in 50% inhibition (IC50, 2 {micro}M) was >35x higher than the maximum plasma concentration (Cmax) after oral administration of the approved dose of ivermectin when given fasted. MethodSimulations were conducted using an available population pharmacokinetic model to predict total (bound and unbound) and unbound plasma concentration-time profiles af...
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