Schistosoma mansoni infection induces long-lived sex-specific metabolic reprogramming of the myeloid lineage
Cortes-Selva, D.; Gibbs, L.; Maschek, J. A.; Van Ry, T.; Rajwa, B.; Cox, J. E.; Amiel, E.; Fairfax, K.
Show abstract
Despite evidence that helminths protect from metabolic disease, a major gap exists in understanding the underlying mechanism(s). Here we demonstrate that bone marrow derived macrophages (BMDM) from S. mansoni infected male ApoE-/- mice have dramatically increased mitochondrial respiration compared to those from uninfected mice. This change associates with increased glucose and palmitate shuttling into TCA cycle intermediates and decreased accumulation of cellular cholesterol esters. Moreover, systemic metabolic modulation by schistosomes is a function of biological sex, where infection protects ApoE-/- male, but not female, mice from obesity and glucose intolerance. Sex-dependence extends to myeloid cells, where reprogramming leads to opposite cholesterol phenotypes in BMDM from females and males. Finally, the metabolic reprogramming of male myeloid cells is transferrable via bone marrow transplantation to an uninfected host, indicating maintenance of reprogramming in the absence of sustained antigen exposure. This work reveals that S. mansoni systemic reprograming of myeloid metabolism is sex-dependent.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion 94%
- The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming 93%
- Fatty acid metabolism in neutrophils promotes lung damage and bacterial replication during tuberculosis. 93%
Similar papers in this journal
- The Bacterial Quorum-Sensing Signal 2-Aminoacetophenone Rewires Immune Cell Bioenergetics through the PGC-1α/ERRα Axis to Mediate Tolerance to Infection 95%
- Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability 94%
- Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice 94%
Similar papers in this journal
- Inhibition of granuloma triglyceride synthesis imparts control of Mycobacterium tuberculosis through curtailed inflammatory responses 94%
- MyD88-Dependent Signaling Drives Toll-Like Receptor-Induced Trained Immunity in Macrophages 94%
- P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis 94%
Similar papers in this journal
- Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation. 95%
- Fatty acid desaturation and lipoxygenase pathways support trained immunity 95%
- IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection 95%
Similar papers in this journal
- T cell Aryl Hydrocarbon Receptor Activity Tunes the Gut Microenvironment to Sustain Autoimmunity. 93%
- Identification of a novel cationic glycolipid in Streptococcus agalactiae that contributes to brain entry and meningitis 92%
- Transcriptional network analysis of transcriptomic diversity in resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system. 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.