A flexible target-specific anti-infection therapeutic platform that can be applied to different microbial species
Mitsunaga, M.; Ito, K.; Nishimura, T.; Miyata, H.; Mizunoe, Y.; Kobayashi, H.; Iwase, T.
Show abstract
The emergence of new microbial pathogens, including drug-resistant strains, complicates treatment, thereby threatening global health. We demonstrated a photoimmuno-antimicrobial strategy (PIAS) that eliminated antibody-targets using a photo-activated anti-pathogen antibody generating mechanical stress that damaged the targets binding sites. PIAS is effective against many pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), the fungal pathogen Candida albicans, and viral particles irrespective of their species or drug-resistance status. Animal experiments demonstrated that PIAS saved mice from fatal infections; microbiome and histochemical analyses indicated no apparent effect on normal host microflora and tissues in PIAS-treated mice. Resistance to PIAS was not observed during the eight years of this study. As a new type of anti-infection therapy, PIAS may contribute to advances in anti-infection strategies.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- In situ reprogramming of gut bacteria by oral delivery 94%
- An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens 93%
- Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy 92%
Similar papers in this journal
- Immunization with peptide encapsulated within synthetic spores activates T cell responses and reduces tumor growth 92%
- Phage-Antibiotic Synergy Is Driven By A Unique Combination Of Antibacterial Mechanism Of Action And Stoichiometry 92%
- Targeting deubiquitinating enzymes (DUBs) and ubiquitin pathway modulators to enhance host defense against bacterial infections 92%
Similar papers in this journal
- The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory 92%
- Bacteriophage uptake by Eukaryotic cell layers represents a major sink for phages during therapy 92%
- Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2 91%
Similar papers in this journal
- Cytoplasmic membrane thinning observed by interfacial dyes is likely a common effect of bactericidal antibiotics 93%
- An engineered prodrug selectively suppresses β-lactam resistant bacteria in a mixed microbial setting 92%
- Highly potent photoinactivation of bacteria using a water soluble, cell permeable, DNA-binding photosensitizer 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.