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Nasal microbiota exhibit neither reproducible nor orderly dynamics following rhinoviral infection

2020-04-17 infectious diseases Title + abstract only
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BackgroundHow human-associated microbial communities resist and respond to perturbations remains incompletely understood. Viral challenge provides one opportunity to test how human microbiota respond to disturbance. MethodsUsing an experimental human rhinovirus infection challenge model, we explored how viral infection may alter microbiota of the upper respiratory tract (URT). Healthy human volunteers were inoculated with HRV serotype 39. Samples were collected by lavage before and after inocul...

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