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COVID-19: A model correlating BCG vaccination to protection from mortality implicates trained immunity

Green, C. M.; Fanucchi, S.; Fok, E. T.; Moorlag, S. J. C. F. M.; Dominguez-Andres, J.; Negishi, Y.; Joosten, L. A. B.; Netea, M. G.; Mhlanga, M. M.

2020-04-15 infectious diseases
10.1101/2020.04.10.20060905 medRxiv
Show abstract

O_LIWe use a data quality model to demonstrate that BCG vaccination is correlated with protection from death from COVID19 C_LIO_LIFrom a mechanistic perspective, BCG is well described to elicit its protective non-specific effects through the process of trained immunity. C_LIO_LITherapeutically enhancing trained immunity may therefore be an important mechanism in protection from the lethal effects of COVID19 C_LI

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.