Back

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

2020-04-14 genetic and genomic medicine Title + abstract only
View on medRxiv
Show abstract

Depression and anxiety are highly prevalent and comorbid psychiatric traits that cause considerable burden worldwide. Previous studies have revealed substantial genetic overlap between depression, anxiety, and a closely related personality trait - neuroticism. Here, we use factor analysis and genomic structural equation modelling (Genomic SEM) to investigate the genetic factor structure underlying 28 items assessing depression, anxiety and neuroticism. Symptoms of depression and anxiety loaded o...

Predicted journal destinations

1
Scientific Reports
701 training papers
Top 24% 8.3%
2
Translational Psychiatry
94 training papers
Top 3% 7.2%
3
Nature Genetics
72 training papers
Top 2% 7.2%
4
Nature Communications
483 training papers
Top 14% 7.2%
5
Nature Human Behaviour
18 training papers
#1 5.9%
6
Psychological Medicine
52 training papers
Top 3% 5.5%
7
The American Journal of Human Genetics
77 training papers
Top 5% 4.6%
8
Molecular Psychiatry
84 training papers
Top 4% 3.8%
9
PLOS ONE
1737 training papers
Top 88% 3.6%
10
Biological Psychiatry
36 training papers
Top 3% 3.6%
11
Human Genetics and Genomics Advances
39 training papers
Top 2% 2.8%
12
Cell Genomics
34 training papers
Top 1% 2.8%
13
Genetics in Medicine
57 training papers
Top 5% 2.6%
14
PLOS Genetics
39 training papers
Top 2% 2.6%
15
Genome Medicine
56 training papers
Top 5% 1.8%
16
Journal of Child Psychology and Psychiatry
18 training papers
Top 1% 1.8%
17
Human Molecular Genetics
28 training papers
Top 3% 1.7%
18
Proceedings of the National Academy of Sciences
100 training papers
Top 10% 1.4%
19
Frontiers in Genetics
32 training papers
Top 4% 1.4%
20
European Journal of Human Genetics
25 training papers
Top 4% 1.4%
21
eLife
262 training papers
Top 38% 1.2%
22
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
15 training papers
Top 0.8% 1.2%
23
BMC Medicine
155 training papers
Top 22% 1.2%
24
Neuropsychopharmacology
29 training papers
Top 4% 1.1%
25
Nature
58 training papers
Top 9% 0.9%
26
Circulation: Genomic and Precision Medicine
30 training papers
Top 7% 0.9%
27
Genes
21 training papers
Top 4% 0.9%
28
Brain
69 training papers
Top 11% 0.7%
29
Bioinformatics
24 training papers
Top 5% 0.7%
30
Nature Medicine
88 training papers
Top 23% 0.7%