Chromosome 1 trisomy overcomes the block of sphingolipid biosynthesis caused by aureobasidin A and confers pleiotropic effects on susceptibility to antifungals in Candida albicans
Xu, Y.; Yang, F.
Show abstract
Sphingolipids are important membrane lipid components of eukaryotic cells. In Candida albicans, chromosome 1 trisomy not only overcame the block of sphingolipid biosynthesis caused by aureobasidin A, but also altered tolerance to three of the four major classes of antifungal drugs. Two haploinsufficient genes on chromosome 1, PDR16 and IPT1, were associated with tolerance to aureobasidin A. This study illustrates an example of multi-drug tolerance caused by aneuploidy in the human fungal pathogen C. albicans.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Genome-wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug-resistance 94%
- A fungal arrestin protein contributes to cell cycle progression and pathogenesis 94%
- Puf4 Mediates Post-transcriptional Regulation of Caspofungin Resistance in Cryptococcus neoformans 93%
Similar papers in this journal
- The HosA histone deacetylase regulates stress resistance, host cell interactions, and virulence in Aspergillus fumigatus 91%
- C-di-AMP levels modulate Staphylococcus aureus cell wall thickness as well as virulence and contribute to antibiotic resistance and tolerance 91%
- Single-Cell RNA Sequencing Defines Developmental Progression and Reproductive Transitions of Pneumocystis carinii 90%
Similar papers in this journal
- A conserved machinery underlies the synthesis of a chitosan layer in the Candida chlamydospore cell wall 93%
- Functional characterization of clinical isolates of the opportunistic fungal pathogen Aspergillus nidulans 93%
- Calcium binding protein Ncs1 is calcineurin-regulated in Cryptococcus neoformans and essential for cell division and virulence 92%
Similar papers in this journal
- Genome-Wide Association for Itraconazole Sensitivity in Non-Resistant Clinical Isolates of Aspergillus fumigatus 90%
- Comparative genome and transcriptome analyses revealing interspecies variations in the expression of fungal biosynthetic gene clusters 90%
- Transcriptomic analysis of quinoa reveals a group of germin-like proteins induced by Trichoderma 86%
Similar papers in this journal
- Synergistic effects of Cyp51 isozyme-specific azole antifungal agents on fungi with multiple cyp51 isozyme genes 95%
- The Ptk2-Pma1 pathway enhances tolerance to terbinafine in Trichophyton rubrum 94%
- Regulation of Phosphatidylinositol-(4,5)-bisphosphate and Active-Rho1p Levels and Distribution is Crucial for Correct Spatio-temporal Cytokinesis and Echinocandin Responses in Candida albicans 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.