Confronting the COVID-19 Pandemic with Systems Biology
Prates, E. T.; Garvin, M. R.; Pavicic, M.; Jones, P.; Shah, M.; Alvarez, C.; Kainer, D.; Demerdash, O.; Amos, B. K.; Geiger, A.; Pestian, J.; Jin, K.; Mitelpunkt, A.; Bardes, E.; Aronow, B.; Jacobson, D.
Show abstract
Using a Systems Biology approach, we integrated genomic, transcriptomic, proteomic, and molecular structure information to provide a holistic understanding of the COVID-19 pandemic. The expression data analysis of the Renin Angiotensin System indicates mild nasal, oral or throat infections are likely and that the gastrointestinal tissues are a common primary target of SARS-CoV-2. Extreme symptoms in the lower respiratory system likely result from a secondary-infection possibly by a comorbidity-driven upregulation of ACE2 in the lung. The remarkable differences in expression of other RAS elements, the elimination of macrophages and the activation of cytokines in COVID-19 bronchoalveolar samples suggest that a functional immune deficiency is a critical outcome of COVID-19. We posit that using a non-respiratory system as a major pathway of infection is likely determining the unprecedented global spread of this coronavirus. One Sentence SummaryA Systems Approach Indicates Non-respiratory Pathways of Infection as Key for the COVID-19 Pandemic
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