Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2
Wang, C.; Wang, S.; Li, D.; Zhao, X.; Han, S.; Wang, T.; Zhao, G.; Chen, Y.; Chen, F.; Zhao, J.; Wang, L.; Sun, W.; Huang, Y.; Su, Y.; Wei, D.; Zhao, J.; Wang, J.
Show abstract
The burgeoning epidemic caused by novel coronavirus 2019 (2019-nCoV) is currently a global concern. Angiotensin-converting enzyme-2 (ACE2) is a receptor of 2019-nCoV spike 1 protein (S1) and mediates viral entry into host cells. Despite the abundance of ACE2 in small intestine, few digestive symptoms are observed in patients infected by 2019-nCoV. Herein, we investigated the interactions between ACE2 and human defensins (HDs) specifically secreted by intestinal Paneth cells. The lectin-like HD5, rather than HD6, bound ACE2 with a high affinity of 39.3 nM and weakened the subsequent recruitment of 2019-nCoV S1. The cloak of HD5 on the ligand-binding domain of ACE2 was confirmed by molecular dynamic simulation. A remarkable dose-dependent preventive effect of HD5 on 2019-nCoV S1 binding to intestinal epithelial cells was further evidenced by in vitro experiments. Our findings unmasked the innate defense function of lectin-like intestinal defensin against 2019-nCoV, which may provide new insights into the prevention and treatment of 2019-nCoV infection.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Engineered Trimeric ACE2 Binds and Locks "Three-up" Spike Protein to Potently Inhibit SARS-CoVs and Mutants 96%
- Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies 94%
- Molecular basis of ligand recognition and activation of human V2 vasopressin receptor 93%
Similar papers in this journal
- Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD 96%
- Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages 95%
- The molecular mechanism of cytoadherence to placenta or tumor cells through VAR2CSA from Plasmodium falciparum 95%
Similar papers in this journal
- Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2 96%
- Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor 95%
- A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus 94%
Similar papers in this journal
- Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative 94%
- Cholesterol-Dependent Membrane Deformation by Metastable Viral Capsids Facilitates Entry 93%
- Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.